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Turmeric The Golden Dust Of Ayurveda

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Use of Turmeric – Turmeric Ayurvedic Applications

Turmeric Ayurvedic Use
: | Synopsis of Turmeric’s Healing Properties | Remedies |
Synopsis of Turmeric’s Healing Properties

Besides flavoring food, to purify the blood and skin conditions remedy is probably the most common use of Turmeric in Ayurveda.
  • The main organs that turmeric treats are the skin, heart, liver and lungs.
  • Turmeric is used for epilepsy and bleeding disorders, skin diseases, to purify the body-mind, and to help the lungs expel Kapha.
  • Activities of Turmeric include: Alterative, analgesic, antibacterial, anti-inflammatory, anti-tumor, anti-allergic, antioxidant, antiseptic, antispasmodic, appetizer, astringent, cardiovascular, carminative, cholagogue, digestive, diuretic, stimulant, and vulnerary.
  • Therapeutic uses of Turmeric: Anemia, cancer, diabetes, digestion, food poisoning, gallstones, indigestion, IBS, parasites, poor circulation, staph infections, and wounds.
  • Turmeric helps to regulate the female reproductive system and purifies the uterus and breast milk, and in men it purifies and builds semen, which is counterintuitive for a pungent bitter.
  • Turmeric reduces fevers, diarrhea, urinary disorders, insanity, poisoning, cough, and lactation problems in general.
  • Turmeric is used to treat external ulcers that respond to nothing else. Turmeric decreases Kapha and so is used to remove mucus in the throat, watery discharges like leucorrhea, and any pus in the eyes, ears, or in wounds, etc.
  • In Ayurvedic cooking, turmeric is everywhere, this multifaceted wonder spice helps
    • Detoxify the liver
    • Balance cholesterol levels
    • Fight allergies
    • Stimulate digestion
    • Boost immunity
    • Enhance the complexion
It is also an antioxidant Ayurveda recognizes turmeric as a heating spice, contributing bitter, pungent and astringent tastes.
Top
Remedies

Anemia

Everyday take a dose of 1 tsp of turmeric juice mixed with honey.


Asthma


Boil 1 cup of milk with 1 tsp of turmeric powder. Drink warm.
Burns

Mix 1 tsp of turmeric with 1 tsp of aloe gel and apply to burnt area.
Conjunctivitis

Mix 1 tbsp of crushed, raw turmeric in 1/3 cup of water. Boil and sieve. 2–3 drops of this mixture may be used in each eye up to 3 times per day.
Complexion

Apply a paste of turmeric on the skin before bed, and wash off after a few minutes. In the morning, remove any remaining yellow tinge with a paste of chickpea flour (besan) and oil.
Dental problems

Mix 1 tsp of turmeric with ½ tsp of salt. Add mustard oil to make a paste. Rub the teeth and gums with this paste twice daily.
Diabetes

½–1 tsp of turmeric should be taken 3 times a day.
Diarrhea

Take ½ tsp of turmeric powder or juice in water, 3 times per day.
Top
Pain

Mix 1 tsp of turmeric and 2 tsp of ginger with water to make a paste. Spread over a cloth, place on the affected area and bandage.
Add 1 tsp of turmeric to 1 cup of warm milk and drink before bed.
Other uses

In cooking, turmeric acts as a yellow coloring agent. It is an important herb in Hindu rituals. It is also a ingredient in cosmetics as it is beneficial for the skin. Burning turmeric can repel insects. Inhaling the smoke can assist in coughs, asthma and congested nasal passages.
Ears, Eyes, Nose and Mouth

Turmeric dust, with alum 1:20, is blown into the ear to treat chronic otorrhea.
Mix a pinch of Turmeric with organic ghee and apply it to the mucus lining of nose to stop the sniffles. It also stops nosebleeds, helps to clear the sinuses, restore a more acute sense of smell, and helps to purify the mind and brain.
Turmeric helps to maintain the shape and integrity of our eyes.
A Turmeric/water decoction, 1:20, is used to treat conjunctivitis and eye disease in general. Soak a cloth in the decoction and then cover the eye with it. This helps to relieve the pain as well.
Top
Turmeric for Stomach and Intestines

Turmeric treats the whole Gastro - Intestinal system.
In general turmeric is used for
  • Weak stomachs
  • Poor digestion
  • Dyspepsia
  • To normalize metabolism
  • To help digest protein
  • To increase the bio-availability of food and the ability of the stomach to withstand digestive acids.
Turmeric is a great carminative, able to calm an upset digestive system by getting rid of gas and distention. Carminatives also tend to increase absorption and nurture the intestinal flora.
Taking Turmeric will work fine to balance an upset digestion. Just take a small spoonful of Turmeric and stir it in a cup of yogurt right after lunch.
Remedy for ‘piles’ is to directly apply a mixture of mustard oil, turmeric, and onion juice. To stop rectal bleeding take a 2 or 3 tablespoons of Turmeric every half hour until the bleeding stops, usually in an hour.
Top
 

spnadmin

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rajkhalsa ji

Did you know that the India Government has created a data base of folk medicine? The government has done this to protect the interests of the Indian people and Indian culture. it seems that turmeric is being packaged by many alternative medicine companies in a variety of different forms using advertising campaigns that claim that these turmeric remedies are their original inventions. This is also happening with many other ancient remedies known in India for thousands of years. By having the data base the government can make intellectual theft claims in international courts of law.

Turmeric is an amazing substance with amazing properties. Thanks for the post.
 

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vegangoth ji

Can't stand that either -- but it does wash out over time or with bleach. If you mix turmeric with a little hand lotion it makes a very good antiseptic cream for cuts and burns.
 
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Has there been any research done this spice and its "remedies"?

Narayanjot Kaur ji, for turmeric to be a good antiseptic, it must kill the bacteria. Now I don't know if it actually kills bacteria... but assuming it does... WHY would you want that in your system??? Humans are a "storehouse" of bacteria. We need most of those bacteria!!
How Much Bacteria Live in Our Bodies?
 

spnadmin

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Bhagat ji

I will leave it to those who like to mince around with quips and come-backs to talk more at length with you on this point.

There is a large body of research -- so much so that the government of India has become concerned that a folk remedy with scientifically demonstrated benefits has been hijacked by big drug companies who can profit big time when the poor of India cannot. I do not have time to produce all of that, do my regular job, keep house, address the needs of my family and moderate this forum. So you might want to do some of the leg work. If I have time on the weekend I will look some of it up.

In truth, I don't think you want staph or strepp bacteria crawling around open sores and burns in numbers greater than your white blood cells can tolerate.

Yes it is an antibacterial. Try it. You will see what I am talking about. As one of the more fact driven members of this forum -- how manmatth of me? - I wouldn't espouse this argument if it didn't measure up for me.
 

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The Health Benefits of Turmeric

Both from a culinary and a medical perspective, the common curry ingredient, turmeric, is one of the most important spices. Researchers have found that it has outstanding properties as an anti-cancer and anti-Alzheimers's agent. Moreover, a landmark survey of all foods in the USA (American Journal of Clinical Nutrition, July 2006) found that turmeric is one of the top five anti-oxidant foods. This makes it one of the most valuable foods that we can use to fight cancer, Alzheimer's disease, aging and conditions associated with free radical damage and oxidative stress.
Turmeric's principal compound, curcumin, is one of the most researched of all the spice compounds. Much of the research and interest in curcumin has centered on its role in preventing and treating breast cancer, but it has also been found to have protective effects against cancers of the bladder, stomach, uterus and cervix. When measured against other phytochemicals, curcumin exhibits at least a ten times greater chemoprotective potency against cancer than its closest rivals.
Turmeric and Cancer
Curcumin is known to protect against cancer through the following mechanisms.

  • Assists the body's natural tumor-suppressing mechanisms.
  • Destroys cancer cells by stimulating apoptosis (programmed cell death) in these cells thereby terminating the immortality so typical of cancer cell lines.
  • Halts tumor proliferation by inhibiting DNA synthesis in the cancer cells and disrupting their replication.
  • Inhibits the formation of the abnormal blood vessels that are essential for tumour growth.
One of turmeric's most promising uses is in the prevention and treatment of breast cancer. Most breast cancers are hormone dependent, requiring estrogen as a growth stimulant. Tamoxifen, which is one of the most used drugs in the treatment of breast cancer, works against this hormone-mediated process, interfering with estrogen's tumor stimulating effects. Curcumin exhibits its anti-estrongenic effects by blocking the estrogen-dependent receptors on tumor cells, thereby interrupting the stimulatory effects of estrogen and slowing tumor growth. Curcumin may be at least as effective as tamoxifen as an estrogen antagonist, with none of the attendant side effects of this drug.
Radiotherapy and chemotherapy are widely used, but imperfect treatments for cancer. Not only do they have serious, debilitating side effects, but tumor cells often develop resistance to these therapeutic modalities. They also activate COX-2 enzymes that are part of the inflammatory process underlying many cancers. Turmeric reduces the activation of COX-2 enzymes and sensitizes the tumor cells to both radiotherapy and chemotherapy, enhancing their therapeutic effects.
Apart from curcumin, other phytochemicals found in turmeric are also known to have chemoprotective effects. Therefore, when it comes to prevention, it is better to take the parent spice, turmeric, rather than the pure curcumin extract. However, the treatment of existing breast cancer may call for more specific dosages of curcumin, the administration of which would need to be supervised by a qualified health practitioner.
Alzheimer's (AD) and Parkinson's Diseases
Curcumin exhibits several properties that make it a valuable preventive agent for these two devastating and increasingly common diseases. Although turmeric is probably most effective as a preventive agent against these illnesses, it may also help by improving cognitive problems and inhibiting further deterioration of existing disease.
Curcumin works against neurodegenerative diseases via the following mechanisms:

  • The accumulation of amyloid protein in the brain is an important factor associated with Alzheimer's disease. Its deposition is associated with oxidative damage and inflammation in the brain tissues. Curcumin is both a potent antioxidant and anti-inflammatory agent and has been shown to suppress oxidative damage, inflammation and the deposition of damaging amyloid protein in the brain. It is possible that it may actually disaggregate existing amyloid plaques and, in so doing, could possibly reverse the course of the disease.
  • Another cause of amyloid deposition in the brain is probably due to the accumulation of certain metals, as higher concentrations of harmful metals have been found in the brains of AD sufferers that in non-AD individuals. Metal molecules that find their way into the brain can both induce amyloid aggregation and are directly toxic to brain cells. Certain chelating agents have shown promise in the treatment of Alzheimer's disease and curcumin's chelating properties enable it to assist the body in the removal of potentially toxic metals from the brain and other tissues.
  • The abnormal proliferation of the brain’s non-neuronal cells is another pathological process that is associated with the development of both Alzheimer's and Parkinson’s diseases. Curcumin prevents the proliferation of these cells which, if allowed to continue growing, cause damage to the brain’s neuronal tissue.
Inflammatory Diseases
Much of turmeric's anti-inflammatory potency can be attributed to curcumin, which is both an effective COX-2 inhibitor as well as a strong antioxidant. However, other phytochemicals found in turmeric, in particular the salicylates, also make a valuable contribution to its anti-inflammatory activities and thereby its preventive properties against arthritis, autoimmune disorders and the general health consequences of chronic systemic inflammation and degenerative diseases.
Chelation
Copper and iron are both essential nutrients but if they accumulate in excessive quantities they can cause serious and sometimes irreversible inflammatory and oxidative damage to a variety of tissues. Curcumin is a powerful chelating agent for both metals, binding to the metal ions and allowing them to be safely excreted in the urine.
Traditional use and modern scientific research have shown that turmeric is one of the most valuable spices in our {censored}nal of disease fighting foods. Synergism between different spices enhances the bioavailability of important compounds such as curcumin. Therefore, to obtain optimum benefit from turmeric, it is important to take it with other common spices.
Those who are serious about maintaining a healthy lifestyle in order to enjoy a good quality of life and reduce the risk of acquiring conditions like Alzheimer's disease and cancer would do well to ensure a daily intake of this golden spice.
About The Author:
Keith Scott is a medical doctor who has a special interest in nutritional medicine. He has written several books on health related topics including Medicinal Seasonings, The Healing Power Of Spices and Natural Home Pharmacy. For more information about the preventive and therapeutic value of turmeric and other spices go to: http://medspice.com.
 

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New study shows how turmeric's curative element works


March 9, 2009 - 0 comments




Washington, March 9:Adding more to the previous studies that have poured health benefits of Turmeric, an essential spice in Indian cuisine that also has long been known for its medicinal properties, a new study has revealed that this herb with a slew of medicinal qualities can spur human cell membranes behave for better health.



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Turmeric is a yellow-coloured rhizome thought to have many medicinal properties including anti-inflammatory, antioxidant and anti-cancer define agents. In India, it is being added to every vegetable and pulses dish cooked in kitchen. Indians also use this yellow Indian spice which belongs to ginger family Zingiberaceae as a readily available antiseptic for cuts, burns and bruises.
Also known as the Indian Saffron, Turmeric was always considered a magical herb in India, and has been used by traditional medicine systems like Ayurveda, Unani, and Siddha for treating wounds and infections. It has also been used in cosmetic preparations.



And, now a team of science experts in the United States have discovered what makes this herbal blood purifier and antiseptic "holy powder", revealing that curcumin is the its main curative ingredient responsible for the magic healing power of Turmeric.


The scientists’ team at Michigan University, led by Indian-origin researcher Ayyalusamy Ramamoorthy, who is a Professor of Biophysics at the University of Michigan (U-M), has claimed that curcumin fights infection and promotes good health by inserting itself into cell membranes and making them more orderly. By entering blood cells, it helps improve cells' resistance to infection and malignancy.



"The membrane goes from being crazy and floppy to being more disciplined and ordered, so that information flow through it can be controlled," says Prof Ramamoorthy.
So far, scientists were not fully aware about how exactly curcumin works inside the body. In the latest research Prof Ramamoorthy and colleagues looked at how curcumin works to increase the body's resistance to disease.


To probe the link between curcumin and membrane, the team used a technique called solid-state nuclear magnetic resonance (NMR) spectroscopy. The researchers found that curcumin actually regulates the action of membrane proteins "indirectly", by altering the physical properties of the membrane.



"Probing high-resolution intermolecular interactions in the messy membrane environment has been a major challenge to commonly used biophysical techniques," Ramamoorthy said.



Prof. Ramamoorthy said his team is now planning to find out if other plant compounds interact with cells the same way as curcumin.


If in the other comparative studies curcumin gives desired results, then it could lead to the development of potent compounds to treat infection and other diseases, explains Ramamoorthy.



"We want to see how these various derivatives interact with the membrane, to see if the interactions are the same as observed. Such a study could lead to development of compounds to treat infection and other diseases," he said.



Prof. Ramamoorthy’s findings is published online in the Journal of the American Chemical Society.


New study shows how turmeric's curative element works | TheMedGuru
 

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Turmeric Medical Benefits, The NIH Studies and Anti Aging Vitamins

According to the Ayurvedic tradition, the turmeric medical benefits include improved healing and reduced infections. It is a readily available antiseptic for use on cuts, burns and bruises. Ayurvedic medicine is practiced primarily in India and other parts of Asia. Only recently have Western practitioners become interested in the plant.

Turmeric powder is used extensively in Indian cuisine. It makes a pleasant tea that is favored in some countries, including Japan. As a dietary supplement, it is used to improve digestion and help heal a variety of stomach problems. It is thought to be good for the teeth, as it has some fluoride content, although people in the US get plenty of fluoride from other sources.

Scientific research has shown that the plant is effective against some types of bacteria. Plants contain a variety of different compounds, each having different biological activity. The active compound in this particular plant is called curcumin.

So, the turmeric medical benefits are related to the curcumin content, but the content varies from plant to plant. Most supplement companies do not measure the active curcumin that is present in the extract, but the better ones do. An extract with a curcumin content of 98% is the highest that is currently available.

Supplement sales increased by 35% between 2004 and 2005, primarily due to an article published in the Wall Street Journal stating that there had been an explosion of research activity concerning curcumin. The ]National Institutes of Health currently has four different clinical trials underway to study the benefit of the compound in the treatment of cancer and Alzheimer's.

For a person that is ill, I would recommend seeking the advice of a doctor of naturopathic medicine. They are more familiar with the use of natural as well as modern treatments and how they may best be combined.

For someone that is looking for a good health supplement, you can get the turmeric medical benefits, along with your daily nutritional needs and a variety of other healthy extracts in a single supplement. There is no need to buy dozens of different supplements and take handfuls of pill every day. You could end up taking something that doesn't work well with something else, either countering its effect of causing an unwanted reaction. Good multi-nutritional supplements are carefully formulated to prevent that type of thing from occurring.

One of the turmeric medical benefits had to do with people suffering from arthritis or other inflammatory diseases. It seems to act like a COX-2 inhibitor. Prescription drugs that act as COX-2 inhibitors have been very effective pain relievers, but they are accompanied by a number of unwanted effects

Natural anti-inflammatories that inhibit COX-2 production are not accompanied by these side effects. Curcumin is only one of the known natural anti-inflammatories.

Researchers feel that these natural anti-inflammatories may reduce our risk of cancer and heart disease by countering the effects of inflammatory foods and toxins that we are exposed to on a daily basis. So, one, of the probable turmeric medical benefits, is to help prevent those life-threatening diseases and help us live longer healthier lives.

Valerie Rosenbaum has spent several years researching anti aging vitamin supplements and natural skincare products. As a result of that effort she has found what she believes to be the best anti aging supplement available on the market today. Learn about what she discovered at her website NaturalBalanceSupplements.com
 

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So far 2 articles summarized for the non scientist. Here is some basic research ongoing of course.


Rapid quantitation of curcumin in turmeric via NMR and LC–tandem mass spectrometry
Food Chemistry, Volume 113, Issue 4, 15 April 2009, Pages 1239-1242
Ahmet C. Gören, Simay Çıkrıkçı, Muhiddin Çergel, Gökhan Bilsel

Turmeric (Curcuma longa)
Clinical Guide to Nutrition & Dietary Supplements in Disease Management, 2003, Pages 669-671
Jennifer R. Jamison MBBCh, PhD, EdD, FACNEM, Grad Dip Human Nutr

Postnatal modulation of hepatic biotransformation system enzymes via translactational exposure of F1 mouse pups to turmeric and curcumin
Cancer Letters, Volume 96, Issue 1, 4 September 1995, Pages 87-93
Anjali Singh, S. P. Singh, R. Bamezai

Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C In Vivo
Food and Chemical Toxicology, Volume 36, Issue 1, January 1998, Pages 73-76
M. J. Mukhopadhyay, A. Saha, A. Mukherjee

Reversal of aflatoxin induced liver damage by turmeric and curcumin
Cancer Letters, Volume 66, Issue 2, 30 September 1992, Pages 115-121
K.B. Soni, A. Rajan, R. Kuttan

Effect of γ-irradiation on the antioxidant activity of turmeric (Curcuma longa L.) extracts
Food Research International, Volume 32, Issue 7, August 1999, Pages 487-490
Suchandra Chatterjee, S. R. Padwal Desai, Paul Thomas

Effect of Turmeric, Turmerin and Curcumin on H2O2-Induced Renal Epithelial (LLC-PK1) Cell Injury
Free Radical Biology and Medicine, Volume 24, Issue 1, 1 January 1998, Pages 49-54
Hari H. P. Cohly, Annelle Taylor, Michael F. Angel, Abdulla K. Salahudeen

Turmeric and curcumin prevents the formation of mutagenic Maillard reaction products
International Congress Series, Volume 1245, November 2002, Pages 327-334
Usha Kolpe, Vidya Ramaswamy, B. S. Satish Rao, Moolky Nagabhushan

High-performance thin layer chromatographic method for quantitative determination of curcuminoids in Curcuma longa germplasm
Food Chemistry, Volume 113, Issue 2, 15 March 2009, Pages 640-644
M. Paramasivam, R. Poi, H. Banerjee, A. Bandyopadhyay

Curcumins as inhibitors of nitrosation in vitro
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 202, Issue 1, November 1988, Pages 163-169
M. Nagabhushan, U.J. Nair, A.J. Amonkar, A.V. D'Souza, S.V. Bhide

Effect of dietary turmeric (curcuma longa) on iron-induced lipid peroxidation in the rat liver
Food and Chemical Toxicology, Volume 32, Issue 3, March 1994, Pages 279-283
A. Ch. Pulla Reddy, B. R. Lokesh

Liquid chromatography–electrospray mass spectrometric analysis of curcuminoids and sesquiterpenoids in turmeric (Curcuma longa)
Journal of Chromatography A, Volume 818, Issue 1, 28 August 1998, Pages 127-132
Xian-Guo He, Long-Ze Lin, Li-Zhi Lian, Michael Lindenmaier

Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification—An in vitro study
Journal of Ethnopharmacology, Volume 110, Issue 2, 21 March 2007, Pages 368-373
Biji T. Kurien, R. Hal Scofield

Inhibition of cyclic AMP-dependent protein kinase by curcumin
Phytochemistry, Volume 42, Issue 3, June 1996, Pages 599-605
M. Hasmeda, G. M. Polya

Turmeric (Curcuma longa)-induced reduction in urinary mutagens
Food and Chemical Toxicology, Volume 29, Issue 10, 1991, Pages 699-706
K. Polasa, B. Sesikaran, T.P. Krishna, K. Krishnaswamy

A dose dependent anti-genotoxic effect of turmeric
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 446, Issue 1, 29 October 1999, Pages 135-139
R. El Hamss, M. Analla, J. Campos-Sanchez, A. Alonso-Moraga, A. Muñoz-Serrano, M. Idaomar

Behavioral, neurochemical and neuroendocrine effects of the ethanolic extract from Curcuma longa L. in the mouse forced swimming test
Journal of Ethnopharmacology, Volume 110, Issue 2, 21 March 2007, Pages 356-363
X. Xia, G. Cheng, Y. Pan, Z.H. Xia, L.D. Kong

In vitro antimutagenicity of curcumin against environmental mutagens
Food and Chemical Toxicology, Volume 25, Issue 7, July 1987, Pages 545-547
M. Nagabhushan, A.J. Amonkar, S.V. Bhide

Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal
Journal of Ethnopharmacology, Volume 67, Issue 1, October 1999, Pages 1-6
D. Eigner, D. Scholz

Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin
Food Chemistry, Volume 98, Issue 4, 2006, Pages 720-724
G.K. Jayaprakasha, L. Jaganmohan Rao, K.K. Sakariah

Inhibition of chemical carcinogenesis by curcumin
Journal of Ethnopharmacology, Volume 27, Issues 1-2, November 1989, Pages 227-233
K.K. Soudamini, R. Kuttan

Effects of curcumin on the formation of benzo[a]pyrene derived DNA adducts in vitro
Cancer Letters, Volume 96, Issue 1, 4 September 1995, Pages 71-80
Shailesh S. Deshpande, Girish B. Maru

Turmeric: The Intriguing Yellow Spice With Medicinal Properties
EXPLORE: The Journal of Science and Healing, Volume 5, Issue 2, March 2009, Pages 114-115
Neena E. Thomas-Eapen

Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets
Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 52, Issue 4, April 1995, Pages 223-227
K. C. Srivastava, A. Bordia, S. K. Verma

Multiple biological activities of curcumin: A short review
Life Sciences, Volume 78, Issue 18, 27 March 2006, Pages 2081-2087
Radha K. Maheshwari, Anoop K. Singh, Jaya Gaddipati, Rikhab C. Srimal

Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1
Chemico-Biological Interactions, Volume 100, Issue 1, 8 March 1996, Pages 41-51
P. F. Firozi, V. S. Aboobaker, R. K. Bhattacharya

Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa
Fertility and Sterility, Volume 90, Issue 3, September 2008, Pages 775-780
Neeta Mathuria, Ramtej Jayram Verma

Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain
Pharmacology Biochemistry and Behavior, Volume 88, Issue 4, February 2008, Pages 511-522
Mahendra Bishnoi, Kanwaljit Chopra, Shrinivas K. Kulkarni

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
Pharmacology Biochemistry and Behavior, Volume 92, Issue 1, March 2009, Pages 39-43
Mohit Kumar Bhutani, Mahendra Bishnoi, Shrinivas K. Kulkarni

Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 515, Issues 1-2, 25 March 2002, Pages 197-202
Yogeshwer Shukla, Annu Arora, Pankaj Taneja

Can curry protect the brain from bilirubin toxicity?
Medical Hypotheses, Volume 72, Issue 6, June 2009, Pages 757-758
Benhur Sirvan Cetin, Didem Yesilirmak, Funda Tuzun, Abdullah Kumral, Nuray Duman, Hasan Ozkan

The relaxant effect of curcumin on porcine coronary arterial ring segments
Vascular Pharmacology, Volume 47, Issue 1, July 2007, Pages 25-30
Pei-Han Xu, Yuan Long, Fang Dai, Zhong-Li Liu

Effect of heat processing of spices on the concentrations of their bioactive principles: Turmeric (Curcuma longa), red pepper (Capsicum annuum) and black pepper (Piper nigrum)
Journal of Food Composition and Analysis, Volume 20, Issues 3-4, May 2007, Pages 346-351
D. Suresh, H. Manjunatha, Krishnapura Srinivasan

Differential synthesis of essential oil in callus derived microshoots of turmeric (Curcuma longa L.) in vitro
Journal of Biotechnology, Volume 136, Supplement 1, October 2008, Page S158
S. Nayak, S. Mohanty, E. Subudhi

Bubbling hookah smoke through heat-solubilized curcumin/turmeric and incorporation of the curry spice as an additive or filter in cigarettes to minimize tobacco smoke-related toxicants
Medical Hypotheses, Volume 73, Issue 3, September 2009, Pages 462-463
Biji T. Kurien, R.H. Scofield

Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways
Vascular Pharmacology, Volume 43, Issue 4, October 2005, Pages 234-241
Muhammad Nabeel Ghayur, Anwarul Hassan Gilani, Maria B. Afridi, Peter J. Houghton

Experimental studies on drying of Zingiber officinale, Curcuma longa l. and Tinospora cordifolia in solar-biomass hybrid drier
Renewable Energy, Volume 30, Issue 14, November 2005, Pages 2097-2109
Jaishree Prasad, V.K. Vijay

Distribution of photosynthetically fixed 14CO2 into curcumin and essential oil in relation to primary metabolites in developing turmeric (Curcuma longa) leaves
Plant Science, Volume 152, Issue 2, 21 March 2000, Pages 165-171
Deeksha Dixit, Neel K. Srivastava

Genetic effects of turmeric and curcumin in mice and rats
Mutation Research/Genetic Toxicology, Volume 79, Issue 2, October 1980, Pages 125-132
Vijayalaxmi

Inhibition of SOS response in E. coli PQ37 by heated turmeric and curcumin
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 379, Issue 1, Supplement 1, September 1997, Page S206
Kalpagam Polasa, A. Nadamuni Naidu, R. Krishnaswamy

Antioxidant capacity of fresh and dried rhizomes from four clones of turmeric (Curcuma longa L.) grown in vitro
Industrial Crops and Products, Volume 25, Issue 2, February 2007, Pages 129-135


Extracts from two frequently consumed spices — Cumin (Cuminum cyminum) and turmeric (Curcuma longa) — Inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets
Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 37, Issue 1, July 1989, Pages 57-64
K. C. Srivastava

Chemistry and biological activities of C. longa
Trends in Food Science & Technology, Volume 16, Issue 12, December 2005, Pages 533-548
G.K. Jayaprakasha, L. Jagan Mohan Rao, K.K. Sakariah

Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC–MS/MS
Journal of Chromatography B, Volume 853, Issues 1-2, 15 June 2007, Pages 183-189
Kuo-Yi Yang, Lei-Chwen Lin, Ting-Yu Tseng, Shau-Chun Wang, Tung-Hu Tsai

Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina
Biochemical and Biophysical Research Communications, Volume 361, Issue 2, 21 September 2007, Pages 528-532
T. Mrudula, P. Suryanarayana, P.N.B.S. Srinivas, G. Bhanuprakash Reddy

An unsymmetrical diarylheptanoid from Curcuma longa
Phytochemistry, Volume 19, Issue 9, 1980, Pages 2031-2032
Vijayalakshmi Ravindranath, M. N. Satyanarayana

Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats
Journal of Ethnopharmacology, Volume 29, Issue 1, April 1990, Pages 25-34
S. Rafatullah, M. Tariq, M.A. Al-Yahya, J.S. Mossa, A.M. Ageel

Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2′-deoxyguanosine, tumorigenesis, but not mortality, induced by γ-ray irradiation
International Journal of Radiation Oncology*Biology*Physics, Volume 53, Issue 3, 1 July 2002, Pages 735-743
Hiroshi Inano, Makoto Onoda


Journal of Chromatography A, Volume 1111, Issue 2, 14 April 2006, Pages 281-286
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Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms
Life Sciences, Volume 75, Issue 14, 20 August 2004, Pages 1701-1711
Ipseeta Mohanty, Dharamvir Singh Arya, Amit Dinda, Sujata Joshi, Keval Kishan Talwar, Suresh Kumar Gupta

Insecticidal Activities of ar-Turmerone Identified in Curcuma longa Rhizome against Nilaparvata lugens (Homoptera: Delphacidae) and Plutella xylostella (Lepidoptera: Yponomeutidae)
Journal of Asia-Pacific Entomology, Volume 4, Issue 2, November 2001, Pages 181-185
Hoi-Scon Lee, Wook-Kyun Shin, Cheol Song, Kwang-Yun Cho, Young-Joon Ahn

Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats
Toxicology Letters, Volume 95, Issue 3, May 1998, Pages 183-193
S. S. Deshpande, V. S. Lalitha, A. D. Ingle, A. S. Raste, S. G. Gadre, G. B. Maru

Oral administration of a turmeric extract inhibits erythrocyte and liver microsome membrane oxidation in rabbits fed with an atherogenic diet
Nutrition, Volume 19, Issue 9, September 2003, Pages 800-804
M. Dolores Mesa, Concepción M. Aguilera, Cesar L. Ramírez-Tortosa, M. Carmen Ramírez-Tortosa, José L. Quiles, Luis Baró, Emilio Martínez de Victoria, Ángel Gil

Comparison of hydrodistillation methods for the deodorization of turmeric
Food Research International, Volume 38, Issues 8-9, October-November 2005, Pages 1087-1096

Studies on curcumin and curcuminoids. XV. Catalytic effect of demethoxy- and bisdemethoxycurcumin on the peroxidation of linoleic acid by 15-lipoxygenase
International Journal of Pharmaceutics, Volume 51, Issue 2, 15 April 1989, Pages 179-181
Hanne Hjorth Tønnesen

Modulation of in vitro murine B-lymphocyte response by curcumin
Phytomedicine, In Press, Corrected Proof, Available online 20 March 2009
D. Decoté-Ricardo, K.K.F. Chagas, J.D.B. Rocha, P. Redner, U.G. Lopes, J.C. Cambier, L. Barros de Arruda, L.M.T. Peçanha

A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats
Food and Chemical Toxicology, Volume 45, Issue 1, January 2007, Pages 64-69
S. Ganiger, H.N. Malleshappa, H. Krishnappa, Geetha Rajashekhar, V. Ramakrishna Rao, Frank Sullivan

Loss of active principles of common spices during domestic cooking
Food Chemistry, Volume 43, Issue 4, 1992, Pages 271-274
K. Srinivasan, K. Sambaiah, N. Chandrasekhara

Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6 Induced by Palmitate in 3T3-L1 Adipocytes through NF-kappaB and JNK Pathway
Biomedical and Environmental Sciences, Volume 22, Issue 1, February 2009, Pages 32-39
Shao-Ling WANG, Ying LI, Ying WEN, Yan-Feng CHEN, Li-Xin NA, Song-Tao LI, Chang-Hao SUN

Chemopreventive and therapeutic effects of curcumin
Cancer Letters, Volume 223, Issue 2, 8 June 2005, Pages 181-190
Annelyse Duvoix, Romain Blasius, Sylvie Delhalle, Michaël Schnekenburger, Franck Morceau, Estelle Henry, Mario Dicato, Marc Diederich

Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats
Pharmacology Biochemistry and Behavior, Volume 82, Issue 1, September 2005, Pages 200-206
Ying Xu, Bao-Shan Ku, Hai-Yan Yao, Yan-Hua Lin, Xing Ma, Yong-He Zhang, Xue-Jun Li

Binding and distribution characteristics of curcumin solubilized in CTAB micelle
Journal of Molecular Liquids, Volume 111, Issues 1-3, 15 April 2004, Pages 161-165
Maurice O. Iwunze

An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen
Mechanisms of Ageing and Development, Volume 114, Issue 3, 14 April 2000, Pages 207-210
Ana Ramirez Boscá, Alfonso Soler, Miguel A. Carrión-Gutiérrez, David Pamies Mira, José Pardo Zapata, Joaquín Diaz-Alperi, August Bernd, Eliseo Quintanilla Almagro, Jaime Miquel

Inhibition of human immunodeficiency virus type-1 integrase by curcumin
Biochemical Pharmacology, Volume 49, Issue 8, 18 April 1995, Pages 1165-1170
Abhijit Mazumder, Krishnamachari Raghavan, John Weinstein, Kurt W. Kohn, Yves Pommier

Inhibition of B(a)P induced strand breaks in presence of curcumin
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 557, Issue 2, 14 February 2004, Pages 203-213
K. Polasa, A. N. Naidu, I. Ravindranath, K. Krishnaswamy

Cytotoxic and cytoprotective activities of curcumin: Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes
Biochemical Pharmacology, Volume 39, Issue 12, 15 June 1990, Pages 1869-1875
Imono Argo Donatus, Sardjoko, Nico P.E. Vermeulen

Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation
European Journal of Pharmacology, Volume 221, Issues 2-3, 20 October 1992, Pages 381-384
Huei-Chen Huang, Tong-Rong Jan, Sheau-Farn Yeh

Curcumin as “Curecumin”: From kitchen to clinic
Biochemical Pharmacology, Volume 75, Issue 4, 15 February 2008, Pages 787-809
Ajay Goel, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal

Capillary electrophoresis with amperometric detection of curcumin in Chinese herbal medicine pretreated by solid-phase extraction
Journal of Chromatography A, Volume 962, Issues 1-2, 12 July 2002, Pages 117-125
Xiuhua Sun, Changlu Gao, Weidong Cao, Xiurong Yang, Erkang Wang

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature
Biochemical Pharmacology, Volume 76, Issue 11, 1 December 2008, Pages 1590-1611
Preetha Anand, Sherin G. Thomas, Ajaikumar B. Kunnumakkara, Chitra Sundaram, Kuzhuvelil B. Harikumar, Bokyung Sung, Sheeja T.Tharakan, Krishna Misra, Indira K. Priyadarsini, Kallikat N. Rajasekharan, Bharat B. Aggarwal

Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 311, Issue 2, 1 December 1994, Pages 249-255
M. Subramanian, Sreejayan, Thomas P.A. Devasagayam, B.B. Singh

Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells
Cell Biology International, Volume 30, Issue 3, March 2006, Pages 221-226
Mingxin Shi, Qiufeng Cai, Luming Yao, Yubin Mao, Yanlin Ming, Gaoliang Ouyang

nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice
Phytomedicine, Volume 15, Issue 8, 1 August 2008, Pages 577-586
Anil Kumar, Anant Singh

The effects of curcumin on depressive-like behaviors in mice
European Journal of Pharmacology, Volume 518, Issue 1, 25 July 2005, Pages 40-46
Ying Xu, Bao-Shan Ku, Hai-Yan Yao, Yan-Hua Lin, Xing Ma, Yong-He Zhang, Xue-Jun Li

Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model
Cancer Letters, Volume 167, Issue 1, 10 June 2001, Pages 33-38
Sílvia Busquets, Neus Carbó, Vanessa Almendro, María T. Quiles, Francisco J. López-Soriano, Josep M. Argilés

Studies on curcumin and curcuminoids. XIII. Catalytic effect of curcumin on the peroxidation of linoleic acid by 15-lipoxygenase
International Journal of Pharmaceutics, Volume 50, Issue 1, 15 February 1989, Pages 67-69
Hanne Hjorth Tønnesen

Modulation of radioresponse of glyoxalase system by curcumin
Journal of Ethnopharmacology, Volume 64, Issue 1, 1 January 1998, Pages 1-7
Dharamainder Choudhary, Dhyan Chandra, Raosaheb K. Kale

Dietary curcumin does not protect kidney in glycerol-induced acute renal failure
Food and Chemical Toxicology, Volume 45, Issue 9, September 2007, Pages 1777-1782
P. Vlahović, T. Cvetković, V. Savić, V. Stefanović

Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling
Biochemical Pharmacology, Volume 58, Issue 7, 1 October 1999, Pages 1167-1172
Bukhtiar H. Shah, Zafar Nawaz, Shamim A. Pertani, Asad Roomi, Hammad Mahmood, Sheikh A. Saeed, Anwar H. Gilani

Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner
Experimental and Molecular Pathology, Volume 84, Issue 3, June 2008, Pages 230-233
Jane L. Watson, Richard Hill, Patrick W. Lee, Carman A. Giacomantonio, David W. Hoskin

Studies on curcumin and curcuminoids. XIV. Effect of curcumin on hyaluronic acid degradation in vitro
International Journal of Pharmaceutics, Volume 50, Issue 2, 1 March 1989, Pages 91-95
Hanne Hjorth Tønnesen

Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes
Life Sciences, Volume 62, Issue 25, 15 May 1998, Pages 2349-2358
Nadia Romiti, Roberto Tongiani, Fabrizio Cervelli, Elisabetta Chieli

Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of γ-radiation
Journal of Surgical Research, Volume 120, Issue 1, July 2004, Pages 127-138
Ganesh Chandra Jagetia, G. K. Rajanikant

Free Radical Reactions of Curcumin in Membrane Models
Free Radical Biology and Medicine, Volume 23, Issue 6, 1997, Pages 838-843
K. Indira Priyadarsini

Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model
Cancer Letters, Volume 264, Issue 2, 18 June 2008, Pages 299-308
Binqiang Tian, Zhiping Wang, Yingmei Zhao, Degui Wang, Yonggang Li, Li Ma, Xiaoming Li, Jing Li, Nan Xiao, Junqiang Tian, Ronald Rodriguez

Curcumin (diferuloylmethane), a singlet oxygen (1O2) quencher
Biochemical and Biophysical Research Communications, Volume 295, Issue 1, 5 July 2002, Pages 62-66
Kumuda C. Das, Chandan K. Das

Abstract

Curcumin (diferuloylmethane) is a major component of food flavoring turmeric (Curcuma longa), and has been reported to be anticarcinogenic and anti-inflammatory. Although curcumin was shown to have antioxidant properties, its exact antioxidant nature has not been fully investigated. In this report we have investigated the possible antioxidant properties of curcumin using EPR spectroscopic techniques. Curcumin was found to inhibit the 1O2-dependent 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) formation in a dose-dependent manner. 1O2 was produced in a photosensitizing system using rose bengal as sensitizer, and was detected as TEMP-1O2 adducts by electron paramagnetic resonance (EPR) spectroscopic techniques using TEMP as a spin-trap. Curcumin at 2.75 μM caused 50% inhibition of TEMP-1O2 adduct formation. However, curcumin only marginally inhibited (24% maximum at 80 μM) reduction of ferricytochrome c in a xanthine–xanthine oxidase system demonstrating that it is not an effective superoxide radical scavenger. Additionally, there was minor inhibition of DMPO–OH adduct formation by curcumin (solubilized in ethanol) when an ethanol control was included in the EPR spin-trapping study, suggesting that curcumin may not be an effective hydroxyl radical scavenger. Together these data demonstrate that curcumin is able only to effectively quench singlet oxygen at very low concentration in aqueous systems.
87.
Curcumin: a potential vaginal contraceptive
Contraception, Volume 68, Issue 3, September 2003, Pages 219-223
Tara Rithaporn, Manoj Monga, Mahadevan Rajasekaran
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G. Radhakrishna Pillai, Anand S. Srivastava, Tarek I. Hassanein, Dharam P. Chauhan, Ewa Carrier

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93. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB
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Ying Xu, Baoshan Ku, Lu Tie, Haiyan Yao, Wengao Jiang, Xing Ma, Xuejun Li

Role of Curcumin in Cancer Therapy
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Shishir Shishodia, Madan M. Chaturvedi, Bharat B. Aggarwal

Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and DMBA-DNA adduct formation by curcumin
Cancer Letters, Volume 103, Issue 2, 5 June 1996, Pages 137-141
Keith Singletary, Christopher MacDonald, Matthew Wallig, Carolyn Fisher

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells
Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 1780, Issue 4, April 2008, Pages 673-679
A. Kunwar, A. Barik, B. Mishra, K. Rathinasamy, R. Pandey, K.I. Priyadarsini

Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment
Biochemical Pharmacology, Volume 54, Issue 8, 15 October 1997, Pages 899-907
Ewa Sikora, Anna Bielak-Zmijewska, Katarzyna Piwocka, Janusz Skierski, Ewa Radziszewska

Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 596, Issues 1-2, 11 April 2006, Pages 81-90
Sutapa Chakraborty, Utpal Ghosh, N.P. Bhattacharyya, R.K. Bhattacharya, Madhumita Roy

Curcumin attenuates aluminium-induced functional neurotoxicity in rats
Pharmacology Biochemistry and Behavior, Volume 93, Issue 1, July 2009, Pages 31-39
Pallavi Sethi, Amar Jyoti, Ejaz Hussain, Deepak Sharma

Stereostructure of curlone, a sesquiterpenoid of Curcuma longa rhizomes
Phytochemistry, Volume 22, Issue 2, 1983, Pages 596-597
 

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