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Guru Granth Sahib
Composition, Arrangement & Layout
ਜਪੁ | Jup
ਸੋ ਦਰੁ | So Dar
ਸੋਹਿਲਾ | Sohilaa
ਰਾਗੁ ਸਿਰੀਰਾਗੁ | Raag Siree-Raag
Gurbani (14-53)
Ashtpadiyan (53-71)
Gurbani (71-74)
Pahre (74-78)
Chhant (78-81)
Vanjara (81-82)
Vaar Siri Raag (83-91)
Bhagat Bani (91-93)
ਰਾਗੁ ਮਾਝ | Raag Maajh
Gurbani (94-109)
Ashtpadi (109)
Ashtpadiyan (110-129)
Ashtpadi (129-130)
Ashtpadiyan (130-133)
Bara Maha (133-136)
Din Raen (136-137)
Vaar Maajh Ki (137-150)
ਰਾਗੁ ਗਉੜੀ | Raag Gauree
Gurbani (151-185)
Quartets/Couplets (185-220)
Ashtpadiyan (220-234)
Karhalei (234-235)
Ashtpadiyan (235-242)
Chhant (242-249)
Baavan Akhari (250-262)
Sukhmani (262-296)
Thittee (296-300)
Gauree kii Vaar (300-323)
Gurbani (323-330)
Ashtpadiyan (330-340)
Baavan Akhari (340-343)
Thintteen (343-344)
Vaar Kabir (344-345)
Bhagat Bani (345-346)
ਰਾਗੁ ਆਸਾ | Raag Aasaa
Gurbani (347-348)
Chaupaday (348-364)
Panchpadde (364-365)
Kaafee (365-409)
Aasaavaree (409-411)
Ashtpadiyan (411-432)
Patee (432-435)
Chhant (435-462)
Vaar Aasaa (462-475)
Bhagat Bani (475-488)
ਰਾਗੁ ਗੂਜਰੀ | Raag Goojaree
Gurbani (489-503)
Ashtpadiyan (503-508)
Vaar Gujari (508-517)
Vaar Gujari (517-526)
ਰਾਗੁ ਦੇਵਗੰਧਾਰੀ | Raag Dayv-Gandhaaree
Gurbani (527-536)
ਰਾਗੁ ਬਿਹਾਗੜਾ | Raag Bihaagraa
Gurbani (537-556)
Chhant (538-548)
Vaar Bihaagraa (548-556)
ਰਾਗੁ ਵਡਹੰਸ | Raag Wadhans
Gurbani (557-564)
Ashtpadiyan (564-565)
Chhant (565-575)
Ghoriaan (575-578)
Alaahaniiaa (578-582)
Vaar Wadhans (582-594)
ਰਾਗੁ ਸੋਰਠਿ | Raag Sorath
Gurbani (595-634)
Asatpadhiya (634-642)
Vaar Sorath (642-659)
ਰਾਗੁ ਧਨਾਸਰੀ | Raag Dhanasaree
Gurbani (660-685)
Astpadhiya (685-687)
Chhant (687-691)
Bhagat Bani (691-695)
ਰਾਗੁ ਜੈਤਸਰੀ | Raag Jaitsree
Gurbani (696-703)
Chhant (703-705)
Vaar Jaitsaree (705-710)
Bhagat Bani (710)
ਰਾਗੁ ਟੋਡੀ | Raag Todee
ਰਾਗੁ ਬੈਰਾੜੀ | Raag Bairaaree
ਰਾਗੁ ਤਿਲੰਗ | Raag Tilang
Gurbani (721-727)
Bhagat Bani (727)
ਰਾਗੁ ਸੂਹੀ | Raag Suhi
Gurbani (728-750)
Ashtpadiyan (750-761)
Kaafee (761-762)
Suchajee (762)
Gunvantee (763)
Chhant (763-785)
Vaar Soohee (785-792)
Bhagat Bani (792-794)
ਰਾਗੁ ਬਿਲਾਵਲੁ | Raag Bilaaval
Gurbani (795-831)
Ashtpadiyan (831-838)
Thitteen (838-840)
Vaar Sat (841-843)
Chhant (843-848)
Vaar Bilaaval (849-855)
Bhagat Bani (855-858)
ਰਾਗੁ ਗੋਂਡ | Raag Gond
Gurbani (859-869)
Ashtpadiyan (869)
Bhagat Bani (870-875)
ਰਾਗੁ ਰਾਮਕਲੀ | Raag Ramkalee
Ashtpadiyan (902-916)
Gurbani (876-902)
Anand (917-922)
Sadd (923-924)
Chhant (924-929)
Dakhnee (929-938)
Sidh Gosat (938-946)
Vaar Ramkalee (947-968)
ਰਾਗੁ ਨਟ ਨਾਰਾਇਨ | Raag Nat Narayan
Gurbani (975-980)
Ashtpadiyan (980-983)
ਰਾਗੁ ਮਾਲੀ ਗਉੜਾ | Raag Maalee Gauraa
Gurbani (984-988)
Bhagat Bani (988)
ਰਾਗੁ ਮਾਰੂ | Raag Maaroo
Gurbani (889-1008)
Ashtpadiyan (1008-1014)
Kaafee (1014-1016)
Ashtpadiyan (1016-1019)
Anjulian (1019-1020)
Solhe (1020-1033)
Dakhni (1033-1043)
ਰਾਗੁ ਤੁਖਾਰੀ | Raag Tukhaari
Bara Maha (1107-1110)
Chhant (1110-1117)
ਰਾਗੁ ਕੇਦਾਰਾ | Raag Kedara
Gurbani (1118-1123)
Bhagat Bani (1123-1124)
ਰਾਗੁ ਭੈਰਉ | Raag Bhairo
Gurbani (1125-1152)
Partaal (1153)
Ashtpadiyan (1153-1167)
ਰਾਗੁ ਬਸੰਤੁ | Raag Basant
Gurbani (1168-1187)
Ashtpadiyan (1187-1193)
Vaar Basant (1193-1196)
ਰਾਗੁ ਸਾਰਗ | Raag Saarag
Gurbani (1197-1200)
Partaal (1200-1231)
Ashtpadiyan (1232-1236)
Chhant (1236-1237)
Vaar Saarang (1237-1253)
ਰਾਗੁ ਮਲਾਰ | Raag Malaar
Gurbani (1254-1293)
Partaal (1265-1273)
Ashtpadiyan (1273-1278)
Chhant (1278)
Vaar Malaar (1278-91)
Bhagat Bani (1292-93)
ਰਾਗੁ ਕਾਨੜਾ | Raag Kaanraa
Gurbani (1294-96)
Partaal (1296-1318)
Ashtpadiyan (1308-1312)
Chhant (1312)
Vaar Kaanraa
Bhagat Bani (1318)
ਰਾਗੁ ਕਲਿਆਨ | Raag Kalyaan
Gurbani (1319-23)
Ashtpadiyan (1323-26)
ਰਾਗੁ ਪ੍ਰਭਾਤੀ | Raag Prabhaatee
Gurbani (1327-1341)
Ashtpadiyan (1342-51)
ਰਾਗੁ ਜੈਜਾਵੰਤੀ | Raag Jaijaiwanti
Gurbani (1352-53)
Salok | Gatha | Phunahe | Chaubole | Swayiye
Sehskritee Mahala 1
Sehskritee Mahala 5
Gaathaa Mahala 5
Phunhay Mahala 5
Chaubolae Mahala 5
Shaloks Bhagat Kabir
Shaloks Sheikh Farid
Swaiyyae Mahala 5
Swaiyyae in Praise of Gurus
Shaloks in Addition To Vaars
Shalok Ninth Mehl
Mundavanee Mehl 5
ਰਾਗ ਮਾਲਾ, Raag Maalaa
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Leukemia Treatment Shows Good Results In A Handful Of Patients
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<blockquote data-quote="Tejwant Singh" data-source="post: 181493" data-attributes="member: 138"><p><a href="http://www.washingtonpost.com/national/health-science/leukemia-treatment-shows-good-results-in-a-handful-of-patients/2013/03/20/b807450e-919a-11e2-bdea-e32ad90da239_story.html" target="_blank">http://www.washingtonpost.com/national/health-science/leukemia-treatment-shows-good-results-in-a-handful-of-patients/2013/03/20/b807450e-919a-11e2-bdea-e32ad90da239_story.html</a></p><p></p><p><strong>Leukemia treatment shows good results in a handful of patients</strong></p><p><strong></strong></p><p>By David Brown, Published: March 20</p><p></p><p>A leukemia therapy in which a patient’s lymphocytes are genetically modified to attack the tumor cells causing the disease has shown dramatic effects in five patients, according to a new study.</p><p></p><p>The treatment appeared to eliminate cancer cells that had grown back after initially being beaten down by chemotherapy. Patients were then able to undergo bone marrow transplants, a grueling but sometimes curative procedure.</p><p></p><p>Five people with relapsed leukemia are rescued at least temporarily by cells programmed to fight the cancer.</p><p></p><p>Might the “immunotherapy” have been curative on its own? That’s the biggest of several unanswered questions.</p><p></p><p>“I’m banking on it,” said Renier J. Brentjens, an oncologist at Memorial Sloan-Kettering Cancer Center in New York, who led the study reported in Science Translational Medicine. “My goal is to remove bone marrow transplant as a requirement to treat this disease.”</p><p></p><p>The four people had B-cell acute lymphoblastic leukemia, a blood cancer in which fewer than one-third of patients survive five years. All had gotten conventional chemotherapy, gone into temporary remission and then relapsed.</p><p></p><p>“These patients have what we term virtually terminal illness, with survival measured in months,” Brentjens said.</p><p></p><p>In the experimental treatment, immune system cells called T lymphocytes were filtered from the bloodstream of each patient. Using a virus to deliver the gene, the cells were then genetically altered so they carried on their surfaces a molecular receptor allowing them to attach to the leukemia cells.</p><p></p><p>The lymphocytes were then infused back into the bloodstream. They homed in on the cancer cells and killed them. They also replicated, making more of themselves.</p><p></p><p>In two patients, the effects were especially notable. Before the treatment, more than 60 percent of the cells in their bone marrow, where leukemia originates, were cancer cells. Eight days after the treatment, no cancer cells were seen under the microscope. Within two months, even the most sensitive molecular search couldn’t find any.</p><p></p><p>Those two patients had a stormy course, however. In the process of killing billions of leukemia cells, the infused lymphocytes released a storm of hormones called cytokines, causing fever, blood pressure instability and other problems. Both patients spent time in intensive care.</p><p></p><p>The plan all along was to have the patients undergo bone marrow transplants. Four of the five patients in the study did. One subsequently died of a blood clot in the lungs. The other three are alive, five to 24 months after their immunotherapy.</p><p></p><p>“The obvious question is what would have happened if we did not give them a bone marrow transplant? Would we have cured them with the T cells alone? We don’t know the answer to that,” Brentjens said.</p><p></p><p>The experience of another patient, a 59-year-old man, suggests the treatment isn’t curative.</p><p></p><p>He had such a severe “cytokine storm” that the physicians gave him high-dose steroids to suppress his immune system. His cancer returned in three months. By that time, he was too ill for a bone marrow transplant and died.</p><p></p><p>Steroids can kill T lymphocytes. They might have done so to the engineered lymphocytes before they had finished their work. Or perhaps those cells are able to only suppress the leukemia cells, not destroy them.</p><p></p><p>Researchers at the University of Pennsylvania and the National Cancer Institute have used a similar strategy against a form of lymphoma and another type of leukemia.</p><p></p><p>Brentjens said the task now is to learn whether it is better used early in treatment — perhaps between rounds of chemotherapy — or with multiple infusions later on if traditional treatment fails.</p></blockquote><p></p>
[QUOTE="Tejwant Singh, post: 181493, member: 138"] [url]http://www.washingtonpost.com/national/health-science/leukemia-treatment-shows-good-results-in-a-handful-of-patients/2013/03/20/b807450e-919a-11e2-bdea-e32ad90da239_story.html[/url] [B]Leukemia treatment shows good results in a handful of patients [/B] By David Brown, Published: March 20 A leukemia therapy in which a patient’s lymphocytes are genetically modified to attack the tumor cells causing the disease has shown dramatic effects in five patients, according to a new study. The treatment appeared to eliminate cancer cells that had grown back after initially being beaten down by chemotherapy. Patients were then able to undergo bone marrow transplants, a grueling but sometimes curative procedure. Five people with relapsed leukemia are rescued at least temporarily by cells programmed to fight the cancer. Might the “immunotherapy” have been curative on its own? That’s the biggest of several unanswered questions. “I’m banking on it,” said Renier J. Brentjens, an oncologist at Memorial Sloan-Kettering Cancer Center in New York, who led the study reported in Science Translational Medicine. “My goal is to remove bone marrow transplant as a requirement to treat this disease.” The four people had B-cell acute lymphoblastic leukemia, a blood cancer in which fewer than one-third of patients survive five years. All had gotten conventional chemotherapy, gone into temporary remission and then relapsed. “These patients have what we term virtually terminal illness, with survival measured in months,” Brentjens said. In the experimental treatment, immune system cells called T lymphocytes were filtered from the bloodstream of each patient. Using a virus to deliver the gene, the cells were then genetically altered so they carried on their surfaces a molecular receptor allowing them to attach to the leukemia cells. The lymphocytes were then infused back into the bloodstream. They homed in on the cancer cells and killed them. They also replicated, making more of themselves. In two patients, the effects were especially notable. Before the treatment, more than 60 percent of the cells in their bone marrow, where leukemia originates, were cancer cells. Eight days after the treatment, no cancer cells were seen under the microscope. Within two months, even the most sensitive molecular search couldn’t find any. Those two patients had a stormy course, however. In the process of killing billions of leukemia cells, the infused lymphocytes released a storm of hormones called cytokines, causing fever, blood pressure instability and other problems. Both patients spent time in intensive care. The plan all along was to have the patients undergo bone marrow transplants. Four of the five patients in the study did. One subsequently died of a blood clot in the lungs. The other three are alive, five to 24 months after their immunotherapy. “The obvious question is what would have happened if we did not give them a bone marrow transplant? Would we have cured them with the T cells alone? We don’t know the answer to that,” Brentjens said. The experience of another patient, a 59-year-old man, suggests the treatment isn’t curative. He had such a severe “cytokine storm” that the physicians gave him high-dose steroids to suppress his immune system. His cancer returned in three months. By that time, he was too ill for a bone marrow transplant and died. Steroids can kill T lymphocytes. They might have done so to the engineered lymphocytes before they had finished their work. Or perhaps those cells are able to only suppress the leukemia cells, not destroy them. Researchers at the University of Pennsylvania and the National Cancer Institute have used a similar strategy against a form of lymphoma and another type of leukemia. Brentjens said the task now is to learn whether it is better used early in treatment — perhaps between rounds of chemotherapy — or with multiple infusions later on if traditional treatment fails. [/QUOTE]
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