Childhood poverty leaves its mark on adult genetics

Soul_jyot · #1 (**permalink**) 26-Oct-2011, 22:50 PM

Childhood poverty leaves its mark on adult genetics

by Andy Coghlan - www.newscientist.com

Genes can be reset during early life in profoundly different ways depending on whether children grow up in privileged or deprived households, a landmark study has shown.

Although children in rich and poor households have very similar sets of genes, the scale of adversity at home dictates which combinations of those genes are switched on or silenced through a process called epigenesis – presumably to maximise the chance of survival.

"They may be protective responses, and the payoff is surviving a threatening childhood," says Marcus Pembrey from the University of Bristol, UK, who co-authored the study whilst working at University College London's Institute of Child Health.

The penalty might be activation of genes that make poorer people more prone to heart disease, diabetes, cancer and other diseases. That could help explain why poorer people often have shorter lives. Epigenetic changes have also recently been linked to conditions that can involve psychosis, including schizophrenia and bipolar disorder.

Haves and have-nots

Pembrey and his colleagues selected 40 men from a group of 3000 born in 1958 – half born into rich households and half born into poor ones. "We selected subjects from the top and bottom 20 per cent according to socioeconomic status, so ensuring we had examples of both extremes," says Pembrey.

The team took blood samples from the men when they were 45, and screened their DNA for any epigenetic changes. They were looking for chemical markings that either silence or activate individual genes. Genes that are methylated – those that have had extra methyl groups added at some stage – tend to be switched off, whereas demethylated groups – having lost methyl groups – are activated.

Focusing on stretches of DNA called promoter regions, which turn genes on or off, the team examined more than 20,000 sites throughout the genome. They found patterns that varied with the wealth or poverty of the men's childhood homes.

The patterns were different between the two groups at almost a third of the sites. Most tellingly, methylation levels were drastically different at 1252 sites if men came from poor households, but only at 545 sites in men from rich backgrounds.

"It's telling us that the epigenetic changes in adult DNA are largely from early life experience," says Pembrey.

Uncertain age

Because the samples were taken in middle age, the researchers couldn't tell exactly when the epigenetic methyl groups were added or subtracted. "We can't say whether the genes were altered in infancy, childhood, fetal life or even the previous generation," says Pembrey. But whenever they were added, they survived to middle age.

Next, Pembrey and his colleagues hope to find out when these changes happen by studying the stored blood of children who took part in the Avon Longitudinal Study of Parents and Children. This project has tracked since birth 14,000 people born in the Bristol area; most are now aged around 20. The blood samples, including cord blood, have been taken every few years. "We can see whether epigenetic patterns are constant from cord blood onwards, or pick up signals from the environment and get reset right up to puberty," says Pembrey.
Reference:: Sikh Philosophy Network http://www.sikhphilosophy.net/arts-and-society/37366-childhood-poverty-leaves-its-mark-adult.html

Many of the affected genes, such as a group called MAP kinases, have functions relating to the signals accepted by cells. What's more, the epigenetic changes tended to be in defined clusters rather than random individual changes, suggesting that entire networks of genes were simultaneously silenced or activated epigenetically.

"They're like huge coordinated switches, as if the whole genome is flipping," says Pembrey. He speculates that the gene networks activated or silenced by these processes are then permanently embedded in the genome. This could cause alterations that blind people to external signals or make them more sensitive to them, he says. Such changes could make people unusually sensitive to threatening situations – useful if they encounter such situations regularly during childhood.
Reference:: Sikh Philosophy Network http://www.sikhphilosophy.net/showthread.php?t=37366

Down the generations

"The paper strengthens the idea that environmental conditions early in life can persistently modify the epigenome and may influence health," says Isabelle Mansuy of the University of Zurich in Switzerland. "But prenatal conditions may also play a role and cannot be excluded," she says.

Last year, Mansuy led a landmark study showing that epigenetic changes in mice deliberately stressed during childhood could be passed down to at least two generations of descendants.

Journal reference: International Journal of Epidemiology, DOI: 10.1093/ije/dyr147

source: http://www.newscientist.com/article/...-genetics.html

Gyani Jarnail Singh · #2 (**permalink**) 27-Oct-2011, 15:53 PM

Interesting..very....very interesting.....its the CHILDHOOD that makes saints or saadhs or chors...and its DNA being passed on and being changed by the environment...so MUCH of what GURBANI says is becoming clearer...day by day as Science matures and learns...